Title

A Histopathological Spectrum of Granulomatous Skin Lesions in a Tertiary Health Centre in Western Maharashtra.

Authors

Subhash R Jambekar, Vikas C Maindad, Vivek DKharolkar, Madhukar M Gavit, Sadanand S Bhise

Abstract

Background: Granulomatous disorders remain to be a major cause of morbidity and mortality amongst samples received in the histopathology department of a tertiary health center. Natural causes of deaths have certain medicolegal concerns in various sudden deaths. The present study was undertaken to assess the histopathological spectrum of various skin conditions that were characterized by a granulomatous reaction pattern on histopathology. Material and Method: A Total of 120 patients who presented with clinical features suggestive of granulomatous disorder of the skin, were enrolled during a period of one year prospectively were included in this study. Statistical analysis and Results: The mean age of patients was 38.09 years with male predominance (61.7%). 93.3% of cases within the state of Maharashtra. 68(59.16%) cases belong Kuppuswamy class 4. Infectious causes (78.07%) outnumbered non-infectious causes (21.93%). Among infections, leprosy (58.29%; 67 cases) and cutaneous Tuberculosis (14.2%; 17 cases) while among noninfectious causes, erythema nodosum (8.3%) was most common. Conclusion: The present study highlights the importance of the histopathological spectrum in arriving at a final diagnosis in cases of granulomatous disorders of the skin. Certain medicolegal concerns can be settled in better way with confirmation of natural causes of deaths.

Keywords

Granulomatous, Histopathology, Leprosy, Spectrum.